A leading figure in independent and experimental cinema and audiovisual production from the late 1960s onwards, Miscuglio was the founder in 1967, with Americo Sbardella and Paolo Castaldini, of Filmstudio 70, the first Italian underground film club. During the 1970s she began her activity as a filmmaker and activist, taking part in the first Italian feminist collectives and films, and in 1976 she organized Kinomata, the first international women's film conference-festival in Rome, with Roni Daopoulo. At the same time, she allowed herself the creative and productive freedom of super8, creating small experimental works. At the end of the 1970s she chose to dedicate herself completely to directing, working mainly for television; one of the very few production fields in which women, albeit to a limited extent, had some room for manoeuvre. Miscuglio's activity is intense and multifaceted, but unknown to most, given the invisibility to which female creativity is often condemned even today - especially if carried out in independent contexts.
